Generation of antioxidant mouse models with graded gene expression
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Generation of antioxidant mouse models with graded gene expression
The 6th ENGII Conference——Oxidative stress is implicated in pathogenesis of many diseases and antioxidant therapy is a plausible method for treatment of these diseases. The studies will test our hypothesis that the mice that have low antioxidant levels would be vulnerable to the diseases related to reactive oxygen species (ROS) and these mice would benefit greatly from antioxidant intervention. The hypothesis will be strengthened by exogenous lipoic acid (LA) administration. On the other hand, mice with an enhanced antioxidant reservoir are more resistant to ROS and should retard the development of the diseases.
Guests ：
Prof. Xianwen Yi
Keyword ：
氧化应激 活性氧 抗氧化剂 小鼠模型 遗传方式Year：2014
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