In Vitro and in Vivo Studies of 1,4-Dihydropyridine DNA Protective Activities

       The 6th ENGII Conference——Abnormal production of reactive oxygen species (ROS), DNA damage produced by free radicals and insufficient DNA repair of these damages are important in pathogenesis of several cardiovascular and metabolic diseases. Search for compounds able to scavenge toxic derivatives of free radicals and to protect DNA against damage is a topical problem. Aim of our study was to evaluate ability of some 1,4-dihydropyridines synthesized in the Latvian Institute of Organic Synthesis to scavenge peroxynitrite, free radicals and to protect DNA against action of ROS and their toxic metabolites. Uncoupling of NO synthases leads to overproduction of superoxide radical, it leads to development of diabetes mellitus complications and causes cardiotoxic effects of doxorubicin.